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KMID : 0357820090330010053
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Korean Journal of Legal Medicine
2009 Volume.33 No. 1 p.53 ~ p.56
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An Autopsy Case of Alzheimer’s Disease
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Kwon Tae-Jung
Won Yu-Jin
Lee Jong-Seok
Ha Hong-Il
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Abstract
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Alzheimer’s disease is the leading cause of dementia. We experienced a case of Alzheimer’s disease who is 83-year-old woman killed by stab with a knife. She had been suffered from dementia for several years. At autopsy, the brain disclosed cortical atrophy in the frontal, temporal and parietal lobes, and hippocampus. Microscopically, many senile plaques and a few neurofibrillary tangles were observed at the cerebral cortex and hippocampus. Senile plaques were characterized by a spherical structure with or without a dense central core of amyloid, associated with dystrophic neurites. Neurofibrillary tangle was an intracellular filamentous lesion in the cell body of neuron. To our knowledge, this is a rare autopsy case in Korea, therefore, we report here-in and review the clinicopathologic features of Alzheimer’s disease.
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KEYWORD
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Alzheimer’s disease, dementia, pathology
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